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- The RNA Helicase Ded1 Regulates Translation and Granule Formation . . .
Ded1 is a conserved RNA helicase that promotes translation initiation in steady-state conditions Ded1 has also been shown to regulate translation during cellular stress and affect the dynamics of stress granules (SGs), accumulations of RNA and protein linked to translation repression
- DED1 | SGD - Saccharomyces Genome Database
DED1 (YOR204W), also known by the alias SPP81, encodes an ATP-dependent DEAD-box RNA helicase, playing a critical role in various aspects of translational regulation
- Condensation of Ded1p Promotes a Translational Switch from Housekeeping . . .
Using ribosome profiling and an in vitro translation assay, we reveal that condensate formation inactivates Ded1p and represses translation of housekeeping mRNAs while promoting translation of stress mRNAs
- The RNA Helicase Ded1 from Yeast Is Associated with the Signal . . .
The purified Ded1 protein is an ATP-dependent RNA-binding protein and an RNA-dependent ATPase, but it was previously found to lack substrate specificity and enzymatic regulation
- Analyses of translation factors Dbp1 and Ded1 reveal the cellular . . .
Ded1 and Dbp1 are paralogous conserved DEAD-box ATPases involved in translation initiation in yeast In long-term starvation states, Dbp1 expression increases and Ded1 decreases, whereas in cycling mitotic cells, Dbp1 is absent
- The RNA Helicase Ded1 Regulates Translation and Granule Formation . . .
Ded1 is a conserved RNA helicase that promotes translation initiation in steady-state conditions Ded1 has also been shown to regulate translation during cellular stress and affect the dynamics of stress granules (SGs), accumulations of RNA and protein linked to translation repression
- Transcriptome-wide analysis of the function of Ded1 in . . . - eLife
Understanding the principles of the biochemistry of mRNA competition for initiation factors cannot be achieved without such a system The authors provide compelling evidence that Ded1 is required for efficient initiation of highly structured mRNAs
- The RNA Helicase Ded1 Regulates Translation and Granule Formation . . .
Abstract Ded1 is a conserved RNA helicase that promotes translation initiation in steady-state conditions Ded1 has also been shown to regulate translation during cellular stress and affect the dynamics of stress granules (SGs), accumulations of RNA and protein linked to translation repression
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