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- Geriatric Impairments and Low Muscle Mass Are Associated with Treatment . . .
There is a high rate of treatment discontinuation (TD) in elderly patients with nte-NDMM, that negatively impacts overall survival (OS) In order to prevent TD identification of unfit and frail patients is a prerequisite, either to withhold or adapt treatment
- Approach to the Older Adult With Multiple Myeloma
Evaluate metrics of frailty using geriatric variables and assessment tools for older adults with multiple myeloma, including octogenarians with multiple myeloma
- Up-Front Treatment of Elderly (Age ≥75 Years) and Frail Patients With . . .
This article provides a summary of phase II and III clinical trials in transplant-ineligible patients with newly diagnosed MM, highlighting outcomes in patients aged ≥75 years and frailty-based outcomes
- Frailty in multiple myeloma: the need for harmony to prevent doing harm
A clinical prediction model for outcome and therapy delivery in transplant-ineligible patients with myeloma (UK Myeloma Research Alliance Risk Profile): a development and validation study
- Implications of Low Muscle Mass across the Continuum of Care: A . . .
Low muscle mass is a predictor of poor morbidity and mortality and occur in several populations This narrative review provides an overview of the importance of low muscle mass on health outcomes for patients in inpatient, outpatient, and long-term care clinical settings
- Dynamics of Geriatric Impairments Are Associated with Risk of Treatment . . .
To investigate this, we prospectively investigated the dynamics of geriatric impairments and the association with treatment discontinuation in patients with NTE-NDMM in the HOVON 123 study The HOVON 123 study is a prospective phase II trial for NTE-NDMM patients ≥75 years
- Ixazomib, Daratumumab, and Low-Dose Dexamethasone in Frail Patients . . .
We designed a phase II trial specifically for frail patients, evaluating the efficacy and tolerability of ixazomib-daratumumab-low-dose-dexamethasone (Ixa-Dara-dex)
- Muscle and Bone Mass Loss in the Elderly Population: Advances in . . .
In this review, we will discuss the muscle and bone mass loss in the elderly population and advances in diagnosis and treatment Keywords: Sarcopenia, Osteopenia, Osteoporosis
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