- EASL Clinical Practice Guidelines: Drug-induced liver injury
In general, hepatocellular type of DILI is more likely to be associated with a poor outcomes and with a higher liver-related mortal-ity 14,16,46,48 However, cholestatic liver injury can also be associ-ated with significant mortality,14,46,48 whereas mixed liver injury seems to have the lowest mortality rate
- Drug-induced cholestasis: causative agents and challenges in . . .
While most infectious hepatitis manifests with a hepatocellular injury pattern, some microorganisms such as Epstein-Barr virus, hepatitis A virus, Salmonella typhi, and Coxiella burnetii can cause cholestatic liver injury [19]
- Drug-Induced Liver Injury — Types and Phenotypes
In-direct injury can represent induction of a new liver condition or an exacerbation of a preexist-ing condition, such as induction of immune-mediated hepatitis or worsening of hepatitis B or C
- Cholestatic Liver Diseases - Mayo Clinic Proceedings
Learning Objectives: On completion of this article, you should be able to (1) develop an approach to evaluate cholestatic liver test elevation, (2) iden-tify how to diagnose acute and chronic cholestatic liver diseases, and (3) recall management approaches to acute and chronic causes of cholestasis
- Navigating Cholestasis Cholestasis (PFIC) in the adult . . .
Secondary cholestasis triggered by a liver issue can be a sign of PFIC 1 Consider reassessing your patient for PFIC if they present with cholestatic pruritus following a recent liver issue, including: • Intrahepatic cholestasis of pregnancy2 • Drug-induced cholestasis3 ed cholestasis (cholestasis triggered by birth contr l,
- New classification of drug induced liver injury (DILI) in . . .
Drug-induced autoimmune hepatitis is a form of DILI, which is defined as patients presenting with acute DILI with serological and or histological markers of idiopathic autoimmune hepatitis
- Drug #8208;Induced Cholestasis - CORE
The clinical presentation of drug-induced cholestasis includes bland cholestasis, cholestatic hepatitis, secondary sclerosing cholangitis, and vanishing bile duct syndrome The associate mortality of cholestatic DILI can be as high as 10%, and thus prompt recognition and removal of the offending agent is of critical importance
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