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The Role of Neutrophils in the Immune System: An Overview Neutrophils are the primary mediators of the rapid innate host defense against most bacterial and fungal pathogens that occurs before the complex humoral and lymphocyte cellular processes of acquired immunity can be brought to bear on an infection
Social networking of human neutrophils within the immune system In this article, we focus on human neutrophils and summarize the recent findings on their heterogeneity and plasticity, as well as on the role that these cells play in linking the innate and adaptive arms of the immune response and in driving immune-mediated pathologies
Neutrophils | British Society for Immunology Neutrophils at the interface between innate and adaptive immunity Neutrophils have historically been viewed as short-lived effector cells of the innate immune system as they undergo spontaneous apoptosis in vitro unless rescued by survival signals such as inflammatory cytokines or microbial compounds (Figure 1, left)
The regulatory roles of neutrophils in adaptive immunity Neutrophils are among the first defense line against invading pathogens, and play an important role in both innate and adaptive immunities Accumulating data showed that neutrophils can switch phenotypes and display distinctive subpopulations (Table 1)