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A new perspective on the interaction between the Vg VGLL1-3 proteins . . . Therefore, the main structural difference between the TEAD-binding domain of these two cofactor families is the presence of an Ω-loop in the Yki YAP proteins (Yki, Yorkie, Drosophila homolog of YAP), but not in the Vg VGLL1-3 proteins
The TEAD TEF Family of Transcription Factor Scalloped Mediates Hippo . . . Here we provide evidence that the TEAD TEF family transcription factor Scalloped (Sd) acts together with the coactivator Yorkie (Yki) to regulate Hpo pathway-responsive genes Sd and Yki form a transcriptional complex whose activity is inhibited by Hpo signaling
The Hippo kinase promotes Scalloped cytoplasmic localization . . . YKI is the downstream effector of the Hippo signaling pathway that plays a key role in the control of tissue growth The core components of this pathway are two kinases, Hippo (HPO) and Warts (WTS), which negatively regulate the activity of the SD YKI complex, retaining YKI in the cytoplasm