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Adrenoleukodystrophy (ALD) - Johns Hopkins Medicine What is ALD? Adrenoleukodystrophy (ALD) is a genetic condition that damages the membrane (myelin sheath) that covers nerve cells in the brain and spinal cord Myelin acts as insulation around the nerve fibers
Adrenoleukodystrophy - Wikipedia Adrenoleukodystrophy (ALD) is a disease linked to the X chromosome It is a result of fatty acid buildup caused by failure of peroxisomal fatty acid beta oxidation which results in the accumulation of very long chain fatty acids in tissues throughout the body
Adrenoleukodystrophy - Symptoms and causes - Mayo Clinic In adrenoleukodystrophy (ALD), your body can't break down very long-chain fatty acids (VLCFAs), causing saturated VLCFA s to build up in your brain, nervous system and adrenal gland The most common type of ALD is X-linked ALD, which is caused by a genetic defect on the X chromosome
Adrenoleukodystrophy (ALD) - American Brain Foundation Adrenoleukodystrophy (ALD) is a rare genetic disorder caused by a mutation on the X chromosome The disease most severely affects boys, beginning between the ages of 4 and 10, although men and women may develop milder symptoms as adults
Adrenoleukodystrophy - United Leukodystrophy Foundation The gene that is defective in X-ALD is called ABCD1, and encodes a protein called ALDP (which stands for ALD protein) This protein resides in the wall of the peroxisome, and is involved in the breakdown of fatty acids However, its exact role in this process is currently unclear
What is ALD? - ALD Alliance Adrenoleukodystrophy, or ALD, is a deadly genetic disease that affects 1 in 17,000 people As it is an X-linked genetic disease, which means, it most severely affects boys and men ALD involves multiple organs in the body, but most prominently affects the brain and spinal cord
What is Adrenoleukodystrophy (ALD)? | ALD Connect Adrenoleukodystrophy (ALD) is a progressive, genetic disease that affects the adrenal glands, the spinal cord, and the white matter (myelin) of the nervous system ALD is considered a rare disease, and affects approximately 1 in 17,000 people worldwide