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Pathology Outlines - Lobular carcinoma in situ (LCIS) classic LCIS classic is a noninvasive, neoplastic proliferation of small, uniform, dyscohesive cells that originates in the terminal duct lobular unit and fills and distends most of the acini of the involved lobule
Pathology Outlines - Fibroadenoma Breast nonmalignant - Fibroadenoma is a benign biphasic tumor composed of a proliferation of both glandular epithelial and stromal components of the terminal duct lobular unit
Pathology Outlines - p120 catenin Stains - p120 cateninMembranous p120 catenin staining pattern is seen in many normal epithelial and nonepithelial tissues (Am J Surg Pathol 2007;31:427, Arch Pathol Lab Med 2014;138:1629, Histochem Cell Biol 2000;114:147) Normal breast epithelium and in situ invasive ductal carcinomas show membranous p120 catenin expression (Histopathology 2016;68:57) Diffuse cytoplasmic p120 catenin
Pathology Outlines - Flat epithelial atypia WHO acceptable: Flat epithelial atypia Also columnar alteration with atypia (columnar cell change with atypia or columnar cell hyperplasia with atypia) Not recommended by WHO: Low grade clinging carcinoma (monomorphous type) Atypical cystic lobules Atypical lobules type A Other (historical): Flat ductal intraepithelial neoplasia grade 1A (DIN1A) Atypical columnar alternation with prominent
Pathology Outlines - Atypical ductal hyperplasia Atypical ductal hyperplasia is an intraductal clonal epithelial cell proliferation with similar histologic features to (but insufficient involvement or volume for the diagnosis of) low grade ductal carcinoma in situ (DCIS)
Pathology Outlines - E-cadherin E-cadherin is a transmembrane protein involved in cellular adhesion and polarity maintenance
Pathology Outlines - LCIS pleomorphic Pleomorphic lobular carcinoma in situ (PLCIS) is a morphologic subtype of lobular carcinoma in situ (LCIS) composed of a noninvasive neoplastic proliferation of large dyscohesive cells with marked nuclear pleomorphism, > 4 times the size of a lymphocyte
Pathology Outlines - LCIS florid Answer A is incorrect because atypical lobular hyperplasia (ALH) shows similar cytologic features to florid LCIS; however, criteria for ALH include either type A or type B cells that distend 50% or more acini within a lobule but not uniformly present throughout the entire terminal duct lobular unit (TDLU) or involves all acini in a TDLU but