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About Analytical Chemistry - ACS Publications Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry
High-Throughput Quantification and Characterization of Dual Payload . . . To expand the available repertoire of analytical methods for the quantification of LNP payloads, we optimized sample deformulation protocols and IP-RP conditions for reliable quantification of multiple payload LNPs together with any associated lipid adduct impurities
Selection of Analytical Technology and Development of Analytical . . . The analytical target profile (ATP), which describes the required quality of the reportable value to be produced by the analytical procedure, enables the analytical scientist to select the best analytical technology on which to develop their procedure (s)
Ongoing Analytical Procedure Performance Verification Using a Risk . . . The analytical target profile (ATP) can be used to provide or guide the establishment of acceptance criteria used to verify the procedure performance during routine use (e g , through a system sample suitability test (SST) or verification criteria applicable to procedure changes or transfers)
Why and How to Control P-Chirality in Phosphorothioated Therapeutic . . . Subsequently, we provide an in-depth analysis of analytical methods used to determine the stereochemical composition of therapeutic oligonucleotides, including liquid chromatography approaches in various separation modes and emerging modern techniques like ion mobility spectrometry