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Angioedema - EMCrit Project CONTENTS overview of angioedema Diagnosis of angioedema (vs other airway obstructive syndromes) Differentiating histamine-mediated versus bradykinin-mediated angioedema Airway management Intubation Extubation histamine-mediated angioedema (This is essentially anaphylaxis!) (Treat this as anaphylaxis ) bradykinin-mediated angioedema Pathophysiology Causes Evaluation Treatment clinical features
Danazol Therapy in Hereditary Angioedema by Lawrence C . . . Herditary angioedema (HAE) is an autosomal dominantly inherited condition in which a deficiency of the inhibitor (C1lnh) of the activated first component of complement is associated with recurrent episodes of edema of the skin, gastrointestinal tract, and larynx The pituitary gonadotropin inhibitor, danazol, has been reported to be effective in preventing attacks and increasing C1lnh levels
Angioedema - WikEM Angioedema is paroxysmal, nondemarcated swelling of dermal or submucosal layers of skin or mucosa Swelling is asymmetric, nonpitting, and nonpruritic, however can be associated with allergic features depending on cause Isolated uvular angioedema, or Quincke's disease, is a relatively rare presentation of angioedema of the upper airway
Entry - #106100 - ANGIOEDEMA, HEREDITARY, 1; HAE1 - OMIM A number sign (#) is used with this entry because hereditary angioedema-1 and -2 (HAE1 and HAE2), which are clinically indistinguishable but biochemically distinct, are both caused by heterozygous mutation in the C1 inhibitor gene (C1NH; SERPING1; 606860) on chromosome 11q HAE caused by homozygous mutation in the C1NH gene has also been reported Description