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The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome . . . Human cells possess three types of proteins, MTH1 (NUDT1), MTH2 (NUDT15) and MTH3 (NUDT18), which have the potential to hydrolyze deoxyribonucleoside di- and triphosphates containing 8-oxoG to the monophosphate, the form of which is unusable for DNA synthesis
lt;br gt;人类 MTH1、MTH2 和 MTH3 蛋白在氧化应激下维持 . . . To elucidate the physiological roles of these enzymes, we constructed single knockout (KO) cell lines for each of the MTH1, MTH2 and MTH3 genes and MTH1 and MTH2-double KO cell lines from the human HeLa S3 line using CRISPR Cas9
Visualization of oxidized guanine nucleotides accumulation in living . . . The expression of MTH1 or NUDT5 almost completely suppressed the errors In contrast, no suppression was found upon MTH2 expression These results indicate that MTH1 and NUDT5 but not MTH2 degrade the oxidized ribonucleotides In this study, more fluorescent foci were formed in MTH2 knockdown cells upon the 8-oxo-dG treatment (Figure 3B)
The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome . . . Human cells possess three types of proteins, MTH1 (NUDT1), MTH2 (NUDT15) and MTH3 (NUDT18), which have the potential to hydrolyze deoxyribonucleoside di- and triphosphates containing 8-oxoG to the monophosphate, the form of which is unusable for DNA synthesis
Crystal structure, biochemical and cellular activities . . . The MTH2 protein, known as NUDT15, is described as the second human homologue of bacterial MutT with 8-oxo-dGTPase activity We present the first NUDT15 crystal structure and demonstrate that NUDT15 prefers other nucleotide substrates over 8-oxo-dGTP