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Recent advances and future therapy development for Alzheimers disease . . . After additional review, in July 2023, the FDA granted full approval to lecanemab for the treatment of early-stage AD This landmark decision supports the “amyloid cascade hypothesis” in its revised form focusing on Aβ oligomers (Kirkitadze et al , 2002) and paves the way for approval of other disease-modifying therapeutics for AD
Accelerating Alzheimers therapeutic development: The past and future . . . Alzheimer's disease (AD) research has entered a new era with the recent positive phase 3 clinical trials of the anti-Aβ antibodies lecanemab and donanemab Why did it take 30 years to achieve these successes? Developing potent therapies for reducing fibrillar amyloid was key, as was selection of patients at relatively early stages of disease
Future of Alzheimer’s Disease Treatment: Combination Therapy and . . . D ecades of clinical and basic scientific research have contributed to our understanding of the diversity and interrelationships of neuropathologic mechanisms associated with the biology of aging and their role in the development and progression of Alzheimer’s disease (AD) (1, 2)
Alzheimers disease drug development pipeline: 2025 The 2025 Alzheimer's disease drug development pipeline is diverse, with agents that address 15 basic disease processes The 2025 Alzheimer's disease drug development pipeline has more trials and more drugs than the 2024 pipeline
Preventing and Treating Alzheimer’s Disease and Related Dementias The Alzheimer’s community has seen remarkable progress in the past year, with the first disease-modifying therapy, lecanemab, receiving traditional approval from the U S Food and Drug Administration (FDA) for the treatment of early Alzheimer’s in July 2023, followed by donanemab receiving traditional approval in July 2024 While NIH did not fund the pivotal phase 3 clinical trials that
A Systematic Review of Clinical Practice Guidelines for Alzheimer’s . . . Advancements in the late-stage clinical development of disease-modifying treatments (DMTs) for Alzheimer's disease (AD), coupled with the emergence of new DMTs, necessitate a significant paradigm shift in the early detection, diagnosis and management of AD This shift requires updates to clinical practice guidelines to align with the latest developments This study presents a systematic
Alzheimers disease drug development pipeline: 2023 - PubMed The Common Alzheimer's Disease Research Ontology (CADRO) was used to identify treatment targets and drug mechanisms Results: On the index date of January 1, 2023, there were 187 trials assessing 141 unique treatments for AD Phase 3 included 36 agents in 55 trials; 87 agents were in 99 Phase 2 trials; and Phase 1 had 31 agents in 33 trials