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CLL and SLL Treatment | IMBRUVICA® (ibrutinib) The most common side effects of IMBRUVICA® in adults with B-cell malignancies (CLL SLL and WM) include low platelet count; diarrhea; tiredness; muscle, bone, and joint pain; low white blood cell count; rash; low red blood cell count (anemia); bruising; and nausea
Ibrutinib improves diffuse large B-cell lymphoma survival NCI researchers have found that adding the targeted therapy ibrutinib (Imbruvica) to standard chemotherapy can improve how long some younger people with a specific form of diffuse large B-cell lymphoma live The new findings come from a new analysis of a previously conducted phase 3 clinical trial called Phoenix
Ibrutinib in Patients with Relapsed or Refractory Diffuse . . . Based on gene profiling, DLBCL can be further classified as activated B-cell-like lymphoma (ABC), germinal center B-cell-like lymphoma (GCB) and primary mediastinal B-cell lymphoma Most patients of DLBCL achieve complete remission (CR) after treatment with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), which is
Imbruvica (Ibrutinib) | Lymphoma News Today A total of 56 patients with various types of B-cell NHL were enrolled in the study The results showed that Imbruvica was well-tolerated across various types of B-cell NHL The FDA approved Imbruvica in 2013 for the treatment of patients with MCL based on the results of an open-label Phase 2 trial (NCT01236391) During the trial, 111 patients
Ibrutinib improves survival for younger people with diffuse . . . “This new analysis provides a compelling rationale for doctors to consider adding ibrutinib to standard chemotherapy for the initial treatment of younger patients with non-GCB DLBCL,” said Wyndham H Wilson, M D , Ph D , senior investigator in the Lymphoid Malignancies Branch and a co-author of the study DLBCL is the most common type of
Imbruvica - European Medicines Agency (EMA) Mantle cell lymphoma In a study in 111 patients with mantle cell lymphoma that did not respond to or had come back after previous treatment, 21% of patients taking Imbruvica had complete response and 47% had partial response (i e the patient improved but some signs of the disease remained)
Official Healthcare Professional Website | IMBRUVICA . . . Cytopenias: In 645 patients with B-cell malignancies who received IMBRUVICA ® as a single agent, grade 3 or 4 neutropenia occurred in 23% of patients, grade 3 or 4 thrombocytopenia in 8%, and grade 3 or 4 anemia in 2 8%, based on laboratory measurements Monitor complete blood counts monthly
Efficacy and safety of ibrutinib in diffuse large B-cell . . . The pooled OR and CR were 64 2 % and 56 9 % in non-germinal center B-cell-like (non-GCB) DLBCL and 68 3 % and 36 0 % in relapsed refractory central nervous system lymphoma (CNSL), respectively The pooled median progression-free and overall survival were 4 54 months and 11 5 months, respectively 70 7 % and 52 6 % patients experienced ≥ grade
(a) Diagnosis of mantle cell lymphoma (MCL) - UHCprovider. com vi HIV-related B-cell lymphoma vii High grade B-cell lymphoma viii Hairy cell leukemia ix Nodal or splenic marginal zone lymphoma (MZL) -AND- (b) Used as second-line or a subsequent therapy Authorization will be issued for 12 months 2 Reauthorization a Imbruvica will be approved based on the following criterion:
Significant efficacy benefit of IMBRUVICA® (ibrutinib) plus . . . As a single agent for the treatment of adult patients with relapsed or refractory (RR) mantle cell lymphoma (MCL) As a single agent for the treatment of adult patients with Waldenström’s macroglobulinaemia (WM) who have received at least one prior therapy, or in first line treatment for patients unsuitable for chemo-immunotherapy