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Anti-CD20 therapies for multiple sclerosis: current status . . . We summarize the rationale regarding the use of anti-CD20 therapies and the results of the main randomized controlled trials and observational studies investigating the efficacy and safety profile of rituximab, ocrelizumab, ofatumumab and ublituximab
096930: B-Cell CD20 Expression | Labcorp It can be used in the evaluation of CD20 deficiency in patients with suspected CD19 deficiency (humoral immunodeficiency), and it can be used to confirm the complete absence of B cells in suspected primary humoral immunodeficiencies using both CD19 and CD20 markers
The ISCCA flow protocol for the monitoring of anti-CD20 . . . Anti-CD20 induce extremely low B cell levels, requiring high-resolution techniques The immune monitoring protocol developed by ISCCA is described and validated, to provide a standardized method for the clinical decision-making process during anti-CD20 therapies in autoimmune diseases
B-Cell CD20 Expression by Flow Cytometry, Quantitative Use to enumerate B cells in peripheral blood or monitor response to rituximab therapy in patients with autoimmune disorders To evaluate for primary B-cell deficiency (eg, agammaglobulinemia, common variable immunodeficiency [CVID], hypogammaglobulinemia), order B Cell Subset Analysis (3002216)
CD20 on B Cells | Test Detail | Quest Diagnostics Patients receiving B-cell depleting therapy with anti-CD20 antibodies can show unusual populations of B cells on reconstitution that express either CD19 or CD20 due to a phenomenon known as trogocytosis Cautions: Timing and consistency in timing of blood collection is critical when serially monitoring patients for lymphocyte subsets
CD20B - Overview: CD20 on B Cells, Blood Confirming complete absence of B cells in suspected primary humoral immunodeficiencies using both CD19 and CD20 markers
Immune monitoring of patients treated with anti-CD20 . . . In anti-CD20 treated autoimmune diseases, the early and long-lasting disappearance of B cells, the slow repopulation by naïve CD27− B cells, and the reduced memory of CD27+ IgG+ B cells are indicators of good response The commitment of IgG-switched memory B cells to plasma cells can be also evaluated
The ISCCA flow protocol for the monitoring of anti-CD20 . . . The usage of therapeutic anti-CD20 MoAbs provides the unique possibility to monitor the individual biological response and to verify the expected mechanism of action of the drug A dedi-cated laboratory monitoring approach can add value to the follow-up of autoimmune diseases treated with therapeutic MoAbs
A Proposed Approach to Screening and Surveillance Labs for . . . Anti-CD20 therapies have proven to be highly effective and safe therapies for multiple sclerosis (MS) and have had rapid uptake in the MS community However, no clear consensus has arisen regarding an approach to screening or surveillance lab monitoring