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AD-BXD - ALZFORUM The BXD genetic reference panel is a set of recombinant inbred mouse strains derived from crossing two inbred strains—C57BL 6J and DBA 2J—that differ at approximately 5 million sites in their genomes (Peirce et al , 2004; Wang et al , 2016) In all, 27 distinct, reproducible F1 AD-BXD strains were created
5xFAD (B6SJL) - ALZFORUM AD-BXDs This panel of strains was created to investigate the influence of genetic background on amyloid-related phenotypes (Neuner et al , 2019) 5xFAD mice on an inbred C57BL 6J background were bred to the BXD reference panel, a series of recombinant inbred strains derived from C57BL 6 and DBA 2J (Taylor et al , 1999)
5xFAD (C57BL6) - ALZFORUM AD-BXDs This panel of strains was created to investigate the influence of genetic background on amyloid-related phenotypes (Neuner et al , 2019) 5xFAD mice on an inbred C57BL 6J background were bred to the BXD reference panel, a series of recombinant inbred strains derived from C57BL 6 and DBA 2J (Taylor et al , 1999)
Missing Ingredient: New Mice Model Alzheimer’s Genetic . . . - ALZFORUM Her group currently is characterizing a total of 70 AD-BXD strains, and will release all the behavioral, transcriptional, and pathology data as it is generated They also have stored frozen brain tissue and peripheral organs from the mice, which are available for study The mice themselves are sold through the Jackson Laboratory —Pat McCaffrey
Can Common Genetic Variation in Mice Nail Genes of Aging, Alzheimer’s . . . Kaczorowski plans to combine systems-genetics approaches using the BXD panel with proteomic and other “omic” studies to create network models to better understand and predict memory decline Kaczorowski and Neuner have already crossed BXD mice with the 5xFAD mouse model of AD in order to identify genetic variants and downstream neuronal
Research Models | ALZFORUM This database provides information about selected rodent models of neurodegenerative disease, including Alzheimer’s, Parkinson’s, and ALS
Harnessing Genetic Complexity to Enhance Translatability of . . . - ALZFORUM Perhaps as many controls This provides results that have good statistical power but not good generality and translatability However, some of the 5XFAD x BXD lines will be cool to use in more focused studies—particularly interventions that delay or prevent age-related decline in performance References: Williams RW, Williams EG
Enhancing face validity of mouse models of Alzheimers . . . - ALZFORUM More recently, Catherine Kaczorowski had a beautiful paper using the BXD recombinant inbred panel to show that even hemizygosity for differing alleles was sufficient to dramatically alter cognitive, biochemical, and transcriptional consequences of the 5xFAD transgenic model (Dec 2018 news; Neuner et al , 2019) I think that this paper from
Research Models Search | ALZFORUM The BXD genetic reference panel is a set of recombinant inbred mouse strains derived from crossing the C57BL 6J and DBA 2J inbred strains APP: Transgenic; PSEN1: Transgenic: Alzheimer's Disease: Transgenic AD-BXD mice develop amyloid plaques by 6 months of age, although the extent of plaque deposition is strain-dependent