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How Smoking Affects the Heart and Blood Vessels - NHLBI, NIH Smoking is a major risk factor for heart disease The chemicals you inhale when you smoke cause damage to your heart and blood vessels that makes you more likely to develop atherosclerosis, or plaque buildup in the arteries Any amount of smoking, even occasional smoking, can cause this damage to the heart and blood vessels Smoking poses an even greater risk for some people, especially for