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Competing endogenous RNA - Wikipedia These competitive endogenous RNAs (ceRNAs) act as molecular sponges for a microRNA through their miRNA binding sites (also referred to as miRNA response elements, MRE), thereby de-repressing all target genes of the respective miRNA family
Integrated analysis of lncRNA–miRNA–mRNA ceRNA network and . . . Competitive endogenous RNA (ceRNA) networks have revealed a new mechanism of interaction between RNAs, and play crucial roles in multiple biological processes and development of neoplasms They might serve as diagnostic and prognosis markers as well as therapeutic targets
Competing endogenous RNA in cancer: a new pattern of gene . . . The competing endogenous RNA (ceRNA) hypothesis was introduced There is a new hypothesis about mRNA, pseudogene transcripts and long noncoding RNAs (lncRNAs) regulate each other’s expression by using microRNA response elements (MREs) to compete for the binding of microMRA (miRNA)
ceRNAs in Cancer: Mechanism and Functions in a Comprehensive . . . Competing endogenous RNAs (ceRNAs) are those competitively binding with shared microRNAs (miRNAs), freeing their counterparts from miRNA-induced degradation, thus actively influencing and connecting with each other