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Mechanical Response of Cytoskeletal Networks For example, pure F-actin solutions, weakly cross-linked actin networks (Gardel et al , 2004a; Xu et al , 1998), and pure microtubule networks (Lin et al , 2007) all show stress-softening behavior Under compression, branched, dendritic networks of F-actin are also shown to reversibly stress soften at high loads (Chaudhuri et al , 2007)
Elastic Behavior of Cross-Linked and Bundled Actin Networks Elastic Behavior of Cross-Linked and Bundled Actin Networks M L Gardel, et al Science 304 , 1301 (2004); DOI: 10 1126 science 1095087 This copy is for your personal, non-commercial use only If you wish to distribute this article to others , you can order high-quality copies for your colleagues, clients, or customers by clicking here
Prof. Margaret L. Gardel Department of Physics University of . . . Prof Margaret L Gardel Department of Physics University of Chicago, Chicago Margaret Gardel is a Professor of Physics at the University of Chicago She is the Director of the University of Chicago MRSEC Her research aims to understand how protein assemblies within eukaryotic cells that control their adhesion, shape and migration
Stressing the limits of focal adhesion mechanosensitivity Gardel ML, Sabass B, Ji L, Danuser G, Schwarz US, Waterman CM: Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed J Cell Biol 2008, 183:999-1005
United we stand – integrating the actin cytoskeleton and cell . . . By quantitatively assessing the retrograde flow dynamics of lamellipodial actin with fluorescent speckle microscopy in addition to measuring cell traction force, correlations between actin retrograde-flow dynamics and the magnitude of the traction force can be obtained (Gardel et al , 2008)