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FDA approves sotorasib with panitumumab for colorectal cancer On January 15, 2025, the Food and Drug Administration approved sotorasib (Lumakras, Amgen Inc ) with panitumumab (Vectibix, Amgen Inc ) for adult patients with KRAS G12C-mutated metastatic
FDA APPROVES LUMAKRAS® (SOTORASIB) IN COMBINATION WITH . . . In June 2017, the FDA approved a refined indication for Vectibix for use in patients with wild-type RAS (defined as wild-type in both KRAS and NRAS as determined by an FDA-approved test for this use) mCRC, specifically as first-line therapy in combination with FOLFOX and as monotherapy following disease progression after prior treatment with
Bristol Myers Squibb Announces U. S. FDA Accelerated Approval . . . INDICATIONS in combination with cetuximab is indicated for the treatment of adult patients with G12C -mutated locally advanced or metastatic colorectal cancer (CRC), as determined by an FDA-approved test, who have received prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy
FDA Approves Adagrasib With Cetuximab in KRAS G12C-Mutated CRC The combination of adagrasib (Krazati) with cetuximab (Erbitux) is now an FDA-approved treatment option for patients with previously treated locally advanced or metastatic colorectal cancer (CRC) with a KRAS G12C mutation Adagrasib is a highly selective and potent oral small-molecule inhibitor of KRAS G12C
Sotorasib Panitumumab FDA Approval Colorectal Cancer The FDA has approved sotorasib with panitumumab for adult patients with KRAS G12C–mutated metastatic CRC A link to this article will be included in this email
FDA Approves First Colorectal Cancer Treatment that Targets . . . The targeted therapy adagrasib received accelerated approved for colorectal cancer caused by a mutation called KRAS-G12C, when used in combination with the drug cetuximab MSK investigators have led much of the research that resulted in this combined drug approval
FDA Approves LUMAKRAS® with VECTIBIX® for KRAS G12C-mutated . . . The lifetime risk of developing CRC is about 1 in 23 Approximately 15-25% of the patients with CRC present with metastatic disease at the time of diagnosis (synchronous metastases) and 50-60% of the patients with CRC will develop metastatic disease during the course of their illness