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ARIA Diagnosis v4 WHAT ARE THE SYMPTOMS OF ARIA? Amyloid-related imaging abnormalities, also known as ‘ARIA’, are a consequence of the presence of amyloid in blood vessel walls (cerebral amyloid angiopathy [CAA]) 1 CAA can cause spontaneous ARIA in patients with Alzheimer’s disease (AD)1
Understanding ARIA - Memory Movement Charlotte Most ARIA cases have no symptoms Occurs in 5-10% of patients Seizures Call your provider promptly if you experience any of these symptoms Routine MRI scans are conducted before starting treatment and periodically during therapy to detect ARIA early If ARIA is detected, your doctor may temporarily stop or adjust the treatment dosage
Amyloid-Related Imaging Abnormalities in 2 Phase 3 . . . - JAMA Network Common associated symptoms among 103 patients with symptomatic ARIA-E or ARIA-H were headache (48 [46 6%]), confusion (15 [14 6%]), dizziness (11 [10 7%]), and nausea (8 [7 8%]) Incidence of ARIA-E was highest in aducanumab-treated participants who were apolipoprotein E ε4 allele carriers
Everything You Wanted to Know About ARIA | Being Patient ARIA encompasses two types of findings that are spotted on brain imaging: ARIA-E, which is more common and involves brain swelling, and ARIA-H, which involves small brain bleeds
ARIA Common in Aducanumab Trials of Early Alzheimer’s The most common symptoms were headache (46 6%), confusion (14 6%), dizziness (10 7%), and nausea (7 8%), though fatigue, visual disturbance, seizure, and gait difficulties also were reported Median duration of symptoms was 5 weeks in the 10 mg kg group
Amyloid-related Imaging Abnormalities (ARIA) •Most cases of ARIA in patients treated with monoclonal antibodies that remove amyloid plaque are asymptomatic; however, ARIA-E may have concurrent symptoms such as headache, confusion, dizziness, and nausea; less likely, gait disturbances, visual impairment, and rarely seizures 4 ARIA can be serious, and life-threatening and may require interve
Recognizing and Managing Adverse Effects of Antiamyloid Therapies There are 2 types of ARIAs: cerebral microhemorrhages or macrohemorrhages (collectively known as ARIA-H), which affect 19% to 26% of patients, and vasogenic edema and sulcal effusions (collectively known as ARIA-E), which affect 13% to 26% of patients in clinical trials 2, 3 Clinicians who are not aware of the adverse effects of AAT may