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Drug Loading and Distribution of ADCs After Reduction or IdeS Digestion . . . High-resolution native mass spectrometry (MS) provides accurate mass measurements (within 30 ppm) of intact ADCs and can also yield drug load distribution (DLD) and average drug to antibody ratio (DAR) in parallel with hydrophobic interaction chromatography (HIC) Native MS is furthermore unique in its ability to simultaneously detect covalent and noncovalent species in a mixture and for HIC
⭑Open Species List⭑ on Toyhouse Disclaimer: This is not a list of all open species, just the ones that I found interesting, creative, and or would actually want to own! I also have this favorites folder with a few extra open semi open species! (I use it to store some I either plan on adding or find too niche to put here) If you want to see some visuals of species upfront it’s worth a look, but it is currently unorganized
Therapeutic protein purity and fragmented species characterization by . . . Positive identification of capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) electropherogram peaks provides information to understand protein molecular characteristics at the structural level It is critical in the design of a robust assay that can accurately resolve, differentiate, and quantify all therapeutic protein components including fragmented species, which are considered as
IdeS, a novel streptococcal cysteine proteinase with unique specificity . . . Fig 3 IdeS is a novel streptococcal cysteine proteinase Purified IdeS or activated SpeB as a control, were separately pre-incubated with proteinase inhibitors prior to incubation with IgG Cleavage was analyzed by 12% SDS–PAGE (A) Untreated IdeS (B–E) IdeS in 1% DMSO (solvent for Z-LVG-CHN 2) (B), iodoacetic acid (C), Z-LVG-CHN 2 (D) or E64 (E) (F) IgG (G–I) Untreated SpeB (G), Z
Minimally-invasive, real-time, non-destructive, species-independent . . . The advantages incurred by IDEs, such as redox cycling and electric field focusing (Kim et al , 2004), may also aid in the detection of either specimen whose oxidation is reversible or non-electrochemically active species via indirect detection schemes such as EIS or voltammetry
IDES The Illinois Department of Employment Security is the code department of the Illinois state government that administers state unemployment benefits, runs the employment service and Illinois Job Bank, and publishes labor market information