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Glucose Transport and Utilization in the Hippocampus: From . . . Later, the growing incidence of type 2 diabetes mellitus (T2D) and dementia in aged populations revealed their high association, in which a reduced neuronal glucose supply has also been considered as a key mechanism, despite hyperglycemia
Sexual and Metabolic Differences in Hippocampal Evolution . . . - MDPI Dysregulation of the insulin-sensitive glucose transporter GLUT4 may explain the comorbidity between type II diabetes and Alzheimer’s GLUT4 colocalizes with the insulin-regulated aminopeptidase IRAP in neuronal vesicles, suggesting an activity-dependent glucose uptake mechanism
Differential Levels of Tryptophan–Kynurenine Pathway . . . - MDPI This study was designed to investigate alterations in the levels of TKP metabolites and the differential regulation of glutamatergic activity by TKP metabolites in the hippocampus, anterior temporal lobe (ATL), and neocortex samples of a lithium–pilocarpine rat model of TLE
TMEM14A Gene Affects Hippocampal Sclerosis in Mesial Temporal Lobe Epilepsy Transcriptomic data from the hippocampi of MTLE-HS subjects and an epilepsy mouse model were examined to assess TMEM14A expression Gene correlation enrichment analysis was performed to investigate potential associations with epilepsy-related phenotypes
Hungry Neurons: Metabolic Insights on Seizure Dynamics - MDPI Recently, novel clinical and preclinical studies explored the role of brain metabolism (i e , glucose utilization) of seizures pathophysiology revealing (in most cases) reduced metabolism in the inter-ictal period and increased metabolism in the seconds preceding and during the appearance of seizures
Hippocampal Cytokine Release in Experimental Epileptogenesis—A . . . This proof-of-concept study demonstrates the feasibility of intraindividual longitudinal monitoring of hippocampal molecular inflammatory processes via repetitive MD over several weeks and sheds light on the kinetics of hippocampal cytokine release during epileptogenesis