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Cowden syndrome - DermNet Cowden disease is a rare inherited condition characterised by overgrowths including mucocutaneous tissues with increased risk of malignancies It is also known as ‘Cowden syndrome’ or ‘multiple hamartoma syndrome’
Cowden syndrome | University of Iowa Health Care Learn more about Cowden syndrome This material supplements information provided by University of Iowa Hospitals Clinics physicians, nurses, genetic counselors, and the rest of your health care team
Cowden syndrome image - DermNet Cowden syndrome is a rare, autosomal dominant, inherited condition characterised by hamartomas in various organs, including breast, thyroid, uterus, brain, and mucocutaneous tissues with increased risk of malignancies
Epidermal naevus syndromes The Cowden naevus is a linear, thick, bumpy, wart-like growth PTEN (phosphatase and tensin homologue) gene mutations have been detected, which are not present in Proteus syndrome, which type 2 segmental Cowden syndrome may resemble (see below)
Trichilemmoma - DermNet Although multiple trichilemmoma associated with Cowden disease is very rare, it is important to re-evaluate patients for this disease if a diagnosis of trichilemmoma is confirmed
Hamartoma — DermNet Other hamartomas Cardiac rhabdomyoma – hamartoma of altered cardiac myocytes Median nerve hamartoma Hypothalamic hamartoma – in Pallister-Hall syndrome Myoepithelial hamartoma – in the pancreas Lisch nodules – pigmented hamartomas in the iris, found in neurofibromatosis type 1 PTEN hamartoma tumour syndromes (PHTS) Cowden syndrome (multiple hamartoma syndrome) — a genetic disorder
Skin signs of gastrointestinal disease - DermNet Cowden syndrome Cowden syndrome, or multiple hamartoma syndrome, is characterised by skin lesions and polyposis coli Trichilemmomas are benign hamartomas of the outer sheath of hair follicles They are: Flesh-coloured, smooth papules 1–5 mm in size Predominantly on face, head, neck and hairline Other skin lesions described in Cowden syndrome
Oral irritated fibroma - DermNet Oral irritated fibroma, Traumatic oral fibroma, Focal intraoral fibrous hyperplasia, Oral polyp, Fibroepithelial polyp of oral mucosa, Irritative hyperplasia of oral mucosa, Oral fibroepithelial polyp Authoritative facts from DermNet New Zealand
Bannayan-Ruvalcaba-Riley syndrome (BRRS) | University of Iowa Health Care What causes Bannayan-Ruvalcaba-Riley syndrome? BRRS is a genetic syndrome usually caused by a mutation in a gene known as PTEN Mutations in this gene have been found in about 60 percent of all people with a clinical diagnosis of Bannayan-Ruvalcaba-Riley syndrome and about 40-80 percent of people with a clinical diagnosis of Cowden syndrome The fact that both conditions are caused by
Tumour of the follicular infundibulum pathology - DermNet Rarely, there are multiple tumours, when they have been associated with Cowden disease They are also known as “follicular infundibulum tumour ” or “infundibuloma” Histology of tumour of the follicular infundibulum In tumour of the follicular infundibulum, sections show an acanthoma composed of pale pink cells and sometimes clear cells