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Neuroimmune interactions in the development and chronification of . . . Emerging evidence suggests that regulatory T cells participate in the resolution of migraine headaches Targeting regulatory T cells may restore the balance between immune activation and suppression to reverse chronic headaches Migraine is highly prevalent and debilitating
Exploring the role of ubiquitination modifications in migraine headaches Calcitonin gene-related peptide (CGRP) plays a dominant role and activation of MAPK and NF-κB signaling pathways regulates neuropeptide release, glial cell activation, and amplification of nociceptive signals Aberrant activation of these pathways drives migraine onset and chronicity
Navigating the Neurobiology of Migraine: From Pathways to . . . - MDPI Researchers have identified key molecules, pathways, and neural circuits that contribute to the initiation and progression of migraine attacks by simulating migraine conditions in controlled experimental settings [23, 24, 25]
Meningeal brain borders and migraine headache genesis We further discuss cortex-to-meninges signaling pathways that could underlie migraine pain in response to endogenous events, such as cortical spreading depolarization (CSD), and explore future directions for the field