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Oral vs. Subcutaneous Semaglutide in Type 2 Diabetes Mellitus This real-world, comparative cohort study aims to evaluate the 12-month effectiveness of oral versus subcutaneous semaglutide in patients with type 2 diabetes mellitus (T2D), with a specific focus on sex-based differences in metabolic response A total of 212 patients were enrolled and evenly assigned to either oral or subcutaneous semaglutide The primary outcome was the change in HbA1c
230-OR: Comparative Effectiveness of Semaglutide in Type 2 Diabetes . . . The objective of this study was to generate real-world evidence to support clinical decision-making by evaluating the long-term effects of once-weekly SC semaglutide (sema) in routine clinical practice SEPRA was a 2-year open-label, randomized, pragmatic study (NCT03596450) comparing the effectiveness of sema vs physician’s choice standard of care (SOC; any antidiabetes drug excluding sema
Effectiveness of semaglutide on survival outcomes in patients with type . . . Background Type 2 diabetes (T2D) and chronic kidney disease (CKD) significantly increase the risk of cardiovascular events, including death and heart failure (HF) The FLOW trial demonstrated that semaglutide reduces all-cause death, cardiovascular events and HF risk in patients with T2D and CKD Since there is a difference in patient characteristics between clinical trials and real-world data
Better Limb Protection With Semaglutide vs Common T2D Meds Among patients with type 2 diabetes and peripheral artery disease or foot ulcers, the use of semaglutide is linked to a markedly lower risk for major limb events than the use of other glucose
Study Finds Oral Semaglutide Vastly Reduces Heart Attacks, Strokes A large clinical trial, co-led by researchers at the UNC School of Medicine, has shown that the popular weight-loss drug significantly reduces cardiovascular events in people with type 2 diabetes, pre-existing cardiovascular disease, and or chronic kidney disease
Real-World Use of Oral Semaglutide in Adults with Type 2 Diabetes in . . . Abstract Introduction: In this phase 4, multicentre, prospective, non-interventional PIONEER REAL Netherlands study, we assessed clinical outcomes associated with once-daily oral semaglutide use in real-world clinical practice in adults living with type 2 diabetes (T2D) naïve to injectable glucose-lowering medication