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Prostate-specific antigen - Wikipedia Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene PSA is a member of the kallikrein -related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women [5] PSA is produced for the ejaculate, where it liquefies semen
Prostate-Specific Antigen - StatPearls - NCBI Bookshelf The primary purpose of any screening exam is to detect the early stages of a pathological condition, enabling timely intervention and preventing unnecessary morbidity or mortality before clinical signs or symptoms develop In prostate cancer screening, an elevated serum prostate-specific antigen (PSA) level is the most common initial laboratory finding, as the vast majority of men with early
Prostate Secretion - an overview | ScienceDirect Topics As prostate cancer cells remain AR-dependent, even in the absence of androgens, circulating levels of PSA in patients with metastatic disease can reach into the hundreds and monitoring levels over time can be a useful indicator of progression and relapse after treatment failure (Partin et al , 1990; Oesterling et al , 1988)
Nonprostatic sources of prostate-specific antigen - PubMed In nonprostatic tissues, PSA exists mainly in its free molecular form, but PSA-ACT complex is also present in most of the fluids that contain PSA, such as breast secretions and amniotic fluid The gene expression and protein production of PSA in nonprostatic tissues are under the regulation of steroid hormones via their receptors
Clinical Collection and Protein Properties of Expressed . . . 4 Clinical Collection of Expressed Prostate Secretions (EPS) in Urine We have concentrated on collecting EPS urine samples from men reporting to the clinic for a prostate biopsy procedure, as this group of men reflects a population where new biomarker assays would be most useful for distinguishing benign prostatic disease from cancers
What is Prostate Specific Antigen (PSA)? | Northern Institute . . . Prostate Specific Antigen (PSA) is a protein enzyme produced by the cells within the prostate gland and secreted into seminal fluid During intercourse the sperm from the testicles, seminal fluid from the prostate and a gel-like secretion from the seminal vesicles is secreted into the part of the urethra inside the prostate
Prostate specific antigen: biology, biochemistry and . . . The ductal epithe-lium is responsible for production and secretion of prostate speci®c antigen (PSA) The basement membrane creates a barrier preventing escape of PSA into the peripheral circulation
FACTS ABOUT PROSTATE CANCER - Centers for Disease Control and . . . The most common screening method is the prostate specific antigen (PSA) test, which measures PSA levels in your blood PSA is a substance the prostate makes Higher PSA levels can show a prostate problem, but it doesn’t always mean you have cancer If your PSA level is high, your doctor may recommend a biopsy