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Human microglial state dynamics in Alzheimer’s disease progression: Cell Altered microglial states affect neuroinflammation, neurodegeneration, and disease but remain poorly understood Here, we report 194,000 single-nucleus microglial transcriptomes and epigenomes across 443 human subjects and diverse Alzheimer’s disease (AD) pathological phenotypes
Microglia May Hold Key to Slowing Alzheimer’s Progression Summary: Alzheimer’s disease is marked by toxic amyloid-beta protein clumps, but some people seem naturally protected A new study reveals that a receptor called ADGRG1 enables immune cells called microglia to effectively clear these harmful plaques Mice lacking this receptor developed rapid
Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention Numerous studies have demonstrated that unbridled microglial activity induces a chronic neuroinflammatory environment, promotes β-amyloid accumulation and tau pathology, and impairs microglia-associated mitophagy Thus, targeting microglia may pave the way for new therapeutic interventions
Microglial activation states and their implications for Alzheimers Disease Herein, we present the latest insights into microglia's involvement in Aβ-related pathologies We discuss their activation states, their role in clearing Aβ, their interactions with other cells during disease progression, and potential strategies to shift their phenotype for therapeutic purposes
Engineered microglia show promise for treating Alzheimer’s, other brain . . . For patients and families grappling with Alzheimer’s and related diseases, the findings offer a hopeful glimpse at a future in which microglial-based cell therapies could precisely and safely counteract the ravages of neurodegeneration
Microglia in Alzheimers disease: pathogenesis, mechanisms, and . . . This review provides a comprehensive summary of the current understanding of microglial involvement in AD, focusing on genetic determinants, phenotypic state, phagocytic capacity, neuroinflammatory response, and impact on synaptic plasticity and neuronal regulation