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Hypercoagulable States in Cardiovascular Disease | Circulation Here, we provide an updated review of hypercoagulable states in cardiovascular disease in 3 sections: (1) inherited hypercoagulable states; (2) acquired hypercoagulable states; and (3) diagnosis and management
Hypercoagulability - StatPearls - NCBI Bookshelf Hypercoagulability or thrombophilia is the increased tendency of blood to thrombose A normal and healthy response to bleeding for maintaining hemostasis involves the formation of a stable clot, and the process is called coagulation
Hypercoagulable states - ACDIS Patients are considered to have a hypercoagulable state if they have laboratory abnormalities or clinical conditions that are associated with increased risk of thrombosis
Hypercoagulability Syndromes | Genetics and Genomics - JAMA Network The antiphospholipid antibody syndrome is probably the most common of the hypercoagulable disorders It is caused by a heterogeneous family of immunoglobulins that bind to plasma proteins that have an affinity for phospholipid surfaces
Hypercoagulable states: an algorithmic approach to laboratory testing . . . New oral anticoagulants are powerful tools for managing hypercoagulable patients; however, their use introduces new challenges in terms of test interpretation and therapeutic monitoring The coagulation laboratory plays an essential role in testing for and treating hypercoagulable states
Blood Clotting Disorders: Types, Signs and Treatment The genetic form of this disorder means you’re born with the tendency to form blood clots Acquired conditions are usually a result of surgery, trauma, medications or a medical condition that increases the risk of forming clots
Coagulation Disorders: Primary Secondary Hypercoagulables Primary (Hereditary) Hypercoagulable State, or Primary Thrombophilia, is caused by several rare genetic abnormalities Factor V Leiden is the most common; others include elevated Factor VIII, and deficiencies in protein S, protein C and antithrombin
Hypercoagulable Workup in Thrombotic Cardiovascular Diseases Inherited hypercoagulable states are not risk factors for arterial thrombosis except possibly in the younger patients, but more importantly, testing for these defects does not alter the management for these patients