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Understanding the Gene-Drug Interaction Chart - GeneSight As you review the GeneSight Psychotropic report, you may see a chart called the gene-drug interaction chart This chart provides information about which pharmacokinetic genes are involved in metabolism of each medication included on the report
Moderate Significant Gene-drug Interaction SAMPLE Clinical Considerations 1: Serum level may be too high, lower doses may be required 6: Use of this drug may increase risk of side effects 8: FDA label identifies a potential gene-drug interaction for this medication
Drug-Gene Interactions (DGIs) A Drug-Gene Interaction (DGI) is an association between a drug and a genetic variant that may affect a patient’s response to drug treatment The selection of which DGIs to include in the PREDICT program starts with published evidence and FDA guidance
eport ate 22 linician ample linician ANTIDEPRESSANTS MODERATE GENE-DRUG . . . 8: FDA label identifies a potential gene-drug interaction for this medication All psychotropic medications require clinical monitoring sertraline (Zoloft®) amitriptyline (Elavil®) clomipramine (Anafranil®) desipramine (Norpramin®) doxepin (Sinequan®) duloxetine (Cymbalta®)
Understanding the GeneSight test algorithm – Unity Laboratories The yellow ‘Moderate Gene-Drug Interaction’ category is like a yellow light – the healthcare provider may want to slow down and be more cautious about how that medication is used Dosage adjustments, closer monitoring, or other strategies may be necessary
How to Interpret the GeneSight® Report | GeneSight The yellow ‘Moderate Gene-Drug Interaction’ category is like a yellow light – the healthcare provider should slow down and be more thoughtful about how that medication is used Dosage adjustments, closer monitoring, or other strategies may be necessary
Drug-Gene Drug-Drug Interactions: How Science Could Help . . . - Genomind Dr Peterson: Pharmacogenomics is the study of how genetic variation can impact drug disposition or response For example, a gene might influence how much drug accumulates in your bloodstream, or whether the drug will give you a severe side effect or have little of the intended effect