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A national study of plasma use in critical care: clinical indications . . . Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here describe overall FFP utilisation in adult critical care, the indications for transfusions, factors indicating the doses used and the effects of FFP use on coagulation Methods We
Balanced massive transfusion ratios in multiple injury patients with . . . Introduction Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions These results have mostly been derived from non-head-injured patients The
The European guideline on management of major bleeding and coagulopathy . . . Background Severe traumatic injury continues to present challenges to healthcare systems around the world, and post-traumatic bleeding remains a leading cause of potentially preventable death among injured patients Now in its fifth edition, this document aims to provide guidance on the management of major bleeding and coagulopathy following traumatic injury and encourages adaptation of the
Prothrombin complex concentrate versus fresh frozen plasma in patients . . . To reverse oral anticoagulant (OAC) therapy, a number of treatment modalities is available Fresh frozen plasma (FFP) is effective and is currently used for coagulation factor replacement, carrying a risk of volume overload, transmission of infective agents and being time consuming Variable and frequently low potency of clotting factors results in minor haemostatic effects compared with
Pre-hospital plasma transfusion: a valuable coagulation support or an . . . Moreover, the INR of FFP is 1 3 [6] Any beneficial effect of plasma to correct slightly elevated INR is futile and plasma has primarily an effect on coagulation parameters with extended volumes and performs best in patients bleeding and coagulopathic
Recombinant factor VIIa for uncontrollable bleeding in patients with . . . Number of blood products transfused (PRC, platelets, FFP, cryoprecipitate) and volume of chest-tube output (for patients with intrathoracic bleeding) were used to quantify bleeding Volumes were recorded from 24 hours before until 24 hours after rFVIIa administration
Comparison of published guidelines for management of coagulopathy and . . . Critically ill patients with COVID-19 are at increased risk for thrombotic complications which has led to an intense debate surrounding their anticoagulation management In the absence of data from randomized controlled clinical trials, a number of consensus guidelines and recommendations have been published to facilitate clinical decision-making on this issue However, substantive differences
Recombinant activated factor VII as an adjunctive therapy for bleeding . . . Introduction We conducted a post-hoc analysis on the effect of recombinant factor VIIa (rFVIIa) on coagulopathic patients from two randomized, placebo-controlled, double-blind trials of rFVIIa as an adjunctive therapy for bleeding in patients with severe trauma Methods Blunt and penetrating trauma patients were randomly assigned to rFVIIa (200 + 100 + 100 μg kg) at 0, 1, and 3 hours after
Massive transfusion practice | Critical Care | Full Text FFP was the commonly used blood product while cryoprecipitate and tranexamic acid were underused Only 56% of patients had FBC and clotting screen to guide transfusion management