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Clinical review: Fresh frozen plasma in massive bleedings - more . . . Fresh frozen plasma (FFP) is indicated for the management of massive bleedings Recent audits suggest physician knowledge of FFP is inadequate and half of the FFP transfused in critical care is inappropriate Trauma is among the largest consumers of FFP Current trauma resuscitation guidelines recommend FFP to correct coagulopathy only after diagnosed by laboratory tests, often when overt
Clinical effectiveness of fresh frozen plasma compared with fibrinogen . . . Introduction Haemostatic therapy in surgical and or massive trauma patients typically involves transfusion of fresh frozen plasma (FFP) Purified human fibrinogen concentrate may offer an alternative to FFP in some instances In this systematic review, we investigated the current evidence for the use of FFP and fibrinogen concentrate in the perioperative or massive trauma setting Methods
A national study of plasma use in critical care: clinical indications . . . Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here describe overall FFP utilisation in adult critical care, the indications for transfusions, factors indicating the doses used and the effects of FFP use on coagulation Methods We
Effect of transfusion of fresh frozen plasma on parameters of . . . Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage Adverse effects of FFP have been well described, including acute lung injury However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion Furthermore, FFP has an endothelial
Transfusion in trauma: thromboelastometry-guided coagulation factor . . . Introduction Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared with fresh frozen plasma (FFP)-based haemostatic therapy Methods This retrospective analysis compared patients from the Salzburg Trauma Centre
Balanced massive transfusion ratios in multiple injury patients with . . . Introduction Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions These results have mostly been derived from non-head-injured patients The
Effect of early administration of fibrinogen replacement therapy in . . . Data on RBC, FFP and platelet transfusion at 24 h was available for all five studies [9, 14,15,16,17] Four of these reported no significant difference in RBC, FFP and platelet requirement at 24 h between the fibrinogen replacement group and the control comparator group [9, 15,16,17]
Clinical review: Prothrombin complex concentrates - evaluation of . . . FFP is also associated with a risk of allergic reactions, such as skin rash, pruritus, urticaria, bronchospasm, angioedema and anaphylactic shock Studies have shown that infusion of FFP is associated with increased risk and frequency of hospital-acquired infections [ 41 ], and that there is a small potential risk of disease transmission with
Prothrombin complex concentrate (PCC) for treatment of trauma-induced . . . Currently, standard component therapy for TIC involves administering tranexamic acid , fresh frozen plasma (FFP), and supplemental fibrinogen and calcium Prothrombin complex concentrates (PCCs) have been proposed for the management of major bleeding and coagulopathy after trauma, particularity when used in conjunction with fibrinogen
Safety and efficacy of prothrombin complex concentrate as first-line . . . Arnekian et al presented the non-randomised comparison of three treatments—four-factor PCC alone, PCC plus FFP or FFP alone—in 77 bleeding patients following cardiac procedures In that study, a low dose of PCC was the most effective in reducing chest tube drainage, reopening for bleeding and blood product use, and no thromboembolic event