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Utilization of Nanoparticles for Treating Age-Related Macular . . . - MDPI The lipid nanoparticles, stabilized with Pluronic F127, showed high encapsulation efficacy (99%) and effectively restored the blood–retinal barrier (BRB) for up to 1 month, although the effect declined by 2 months due to rapid clearance of the small-sized particles
Atorvastatin-loaded solid lipid nanoparticles as eye drops: proposed . . . Statins, widely prescribed for cardiovascular diseases, are also being eyed for management of age-related macular degeneration (AMD) Poor bioavailability and blood-aqueous barrier may however limit significant ocular concentration of statins following oral administration
Drug delivery strategies with lipid-based nanoparticles for Alzheimer’s . . . In this review, we explore the potential applications of lipid-based nanoparticles (LBNs) in the treatment of AD Given the intricate nature of AD progression and the current uncertainties in treatment pathways, we propose hypotheses to elucidate the potential mechanisms underlying its development
Effects of Age on Lipid Nanoparticle Delivery and mRNA Vaccination While other researchers are examining age-related immune system impairment, this research is unique because it will determine age-related effects on the lipid nanoparticle (LNP) mRNA delivery process
Lipid nanoparticles: Composition, formulation, and application In this review, we first introduce the LNP components, highlighting their critical roles in encapsulation, stability, delivery efficiency, and tissue tropism Next, we summarize different techniques for LNP formulation with a focus on their advantages and disadvantages