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Engineering TALE-linked deaminases to facilitate precision . . . In brief Most mitochondrial genetic diseases are caused by A-to-G or C-to-T point mutations in the human mitochondrial DNA (mtDNA) Engineered TALE-linked deaminases with fine-tuned enzyme activity largely avoid RNA off-target edits in the transcriptome and bystander edits at the target site, enabling creation of mouse models with pathogenic A-to-G mutations
A PSMA-targeted bispecific antibody for prostate cancer . . . Despite the development of next-generation antiandrogens, metastatic castration-resistant prostate cancer (mCRPC) remains incurable Here, we describe a unique semisynthetic bispecific antibody that uses site-specific unnatural amino acid conjugation to combine the potency of a T cell–recruiting anti-CD3 antibody with the specificity of an imaging ligand (DUPA) for prostate-specific membrane