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ALZFORUM | NETWORKING FOR A CURE A large proteogenomic study identified 49 pQTLs, in either CSF or plasma, linked to cerebral small vessel disease Immune and ECM proteins predominated
Therapeutics - ALZFORUM AD Target Therapy Types The two tables below organize the therapeutics within this database by therapy type and proposed target type The number of therapeutics within each category is indicated according to the highest phase each therapeutic has achieved in U S clinical trials For example, if a given therapeutic is in both Phase 2 and Phase 3 trials, it is included in the Phase 3 total
Exenatide - ALZFORUM The short-acting form of exenatide is administered by twice-daily subcutaneous self-injection; a long-acting preparation is injected just once a week In mice, exenatide readily crossed the blood-brain barrier, while other GLP-1 mimetics liraglutide and semaglutide did not (Salameh et al , 2020)
Empagliflozin - ALZFORUM Empagliflozin belongs to the gliflozin class of glucose-lowering agents that includes dapagliflozin These drugs inhibit the sodium-glucose cotransporter-2 (SGLT2), which is responsible for 90 percent of glucose reabsorption into the kidney As a result, excess glucose is secreted via the urine, helping reduce blood glucose, alleviate glucose toxicity, improve insulin sensitivity, and promote
Liraglutide - ALZFORUM Background Liraglutide is an analog of glucagon-like peptide 1 GLP-1 is a hormone that is produced in the gut and activates receptors in the gut, liver, and pancreas to control blood-sugar levels and reduce insulin resistance Liraglutide and related GLP-1 mimetics cause body weight loss and reduce the risk of cardiovascular events, stroke, and dementia in people with diabetes
ALZFORUM | NETWORKING FOR A CURE Chang YF, Zhang D, Hu WM, Liu DX, Li L Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis J Clin Neurosci 2020 Nov;81:234-239 Epub 2020 Oct 14 PubMed Recommends Please login to recommend the paper