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Scientists develop a rapid gene-editing screen to find . . . - MIT News Caption: Using a variant of CRISPR genome-editing known as prime editing, MIT researchers have developed a method to screen cancer-associated genetic mutations much more easily and quickly than any existing approach This illustration, by Samuel Gould’s brother Owen Gould, is an artistic interpretation of the research and the idea of
Genetic engineering | MIT News | Massachusetts Institute of Technology Lydia Villa Komaroff PhD ’75 speaks with NPR reporter Emily Kwong about her work in gene editing Biotechnology and genetic engineering were “enormously impactful,” says Komaroff “So impactful that molecular biology pretty much disappeared as a field, it has become a tool that is of use in every field of biology and medicine today ”
An ancient RNA-guided system could simplify delivery of gene . . . - MIT News “Nature is pretty incredible,” says Zhang, who is also an investigator at the McGovern Institute and the Howard Hughes Medical Institute, a core member of the Broad Institute, a professor of brain and cognitive sciences and biological engineering at MIT, and co-director of the K Lisa Yang and Hock E Tan Center for Molecular Therapeutics
An on-off switch for gene editing - MIT News Genetic engineering 2 0 The classic CRISPR-Cas9 system uses a DNA-cutting protein called Cas9 found in bacterial immune systems The system can be targeted to specific genes in human cells using a single guide RNA, where the Cas9 proteins create tiny breaks in the DNA strand Then the cell’s existing repair machinery patches up the holes
Keeping genetic engineering localized - MIT News Genetic engineering tools that spread genes within a target species have the potential to humanely control harmful pests as well as eradicate parasitic diseases such as malaria The tools, known as gene drives, ensure that engineered organisms transmit desired genetic variants to their offspring
Genetics | MIT News | Massachusetts Institute of Technology Professor William Thilly, whose research illuminated the effects of mutagens on human cells, dies at 79 A professor of genetics, toxicology, and biological engineering, Thilly pushed himself and his students to develop solutions to real-world problems
Gene circuits enable more precise control of gene therapy “In theory, gene supplementation can solve monogenic disorders that are very diverse but have a relatively straightforward gene therapy fix if you could control the therapy well enough,” says Katie Galloway, the W M Keck Career Development Professor in Biomedical Engineering and Chemical Engineering and the senior author of the new study
A more effective experimental design for engineering a cell . . . - MIT News Researchers from MIT and Harvard University developed a new, computational approach that can efficiently identify optimal genetic perturbations based on a much smaller number of experiments than traditional methods Caroline Uhler, a professor in the Department of Electrical Engineering and Computer Science (EECS), is co-senior author on the paper
Restoring healthy gene expression with programmable therapeutics - MIT News Young believes correcting genetic expression without modulating the genes themselves will be a powerful approach to treating a range of complex diseases “Genetics is a powerful indicator of where a deficiency lies and how you might reverse that problem,” Young says