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Lilly Announces Complete Response Letter for Sintilimab in Combination . . . INDIANAPOLIS, March 24, 2022 PRNewswire -- Eli Lilly and Company (NYSE: LLY) today announced that the U S Food and Drug Administration (FDA) has issued a complete response letter (CRL) for the Biologics License Application (BLA) for the investigational medicine sintilimab injection, a PD-1 inhibitor in combination with pemetrexed and platinum chemotherapy for the first-line treatment of