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Linker Design for the Antibody Drug Conjugates: A Comprehensive Review Inspired by the "magic bullet" concept proposed over a century ago, antibody-drug conjugates (ADCs) are developed to enhance cancer therapy by linking monoclonal antibodies to a cytotoxic payload, aiming to overcome the limitations of conventional chemotherapy
Chemical Evolution of Antibody–Drug Conjugates . . . - ScienceDirect Abstract Antibody–drug conjugates (ADCs) have transformed the treatment of hematologic malignancies by coupling antibody selectivity with potent cytotoxic payloads Their clinical performance depends largely on chemical design, particularly linker stability and conjugation strategy
A Simple Review of Antibody-Drug Conjugates (ADCs): Mechanisms . . . Despite these advances, ADCs still face challenges, including drug-to-antibody ratio (DAR) optimization, off-target toxicity, resistance mechanisms, and scalable manufacturing This article reviews the mechanism of action, clinical development, design considerations, and future trends in ADC technology 2 Mechanism of Action of ADCs
Emerging conjugation strategies and protein engineering technologies . . . Here we provide a review of developing methods for ADC construction These include enzymatic methods, oligosaccharide remodelling, and technologies using genetic code expansion techniques The virtues and limitations of each technology are discussed