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Hemoglobin H disease - Wikipedia Hemoglobin H disease, also called α-thalassemia intermedia, is a disease affecting hemoglobin, the oxygen carrying molecule within red blood cells It is a form of α-thalassemia which most commonly occurs due to deletion of 3 out of 4 of the α-globin genes [1]
Hemoglobin H Disease: Treatment Guidelines | Northern California . . . HbH caused by deletion of three genes (deletional HbH) is less severe than cases in which two genes are deleted and the third gene has a point mutation (non-deletional HbH) HbH Constant Spring (HCS) is the most common form of non-deletional HbH in the United States
Newborn Screening for HbH Disease - Health Resources and Services . . . There are 2 types of HbH Disease: deletional and nondeletional Most children have the first type HbH Disease can cause problems with making blood These problems can affect many parts of the body and lead to death during young adulthood Hematopoietic stem cell transplant may cure HbH Disease
Hemoglobin H Disease - an overview | ScienceDirect Topics HbH is common in Southeast Asia and around the Mediterranean, but occurs rarely in those of African descent Most patients have Hb 7–10 g dl with few symptoms and mild hepatosplenomegaly They may require occasional transfusions during pregnancy or episodes of infection
Hemoglobin H disease - Orphanet Hemoglobin H disease (HbH) disease belongs to the group of nontransfusion-dependent thalassemia HbH disease predominates in people of Southeast Asian, Middle Eastern and Mediterranean descent
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Haemoglobin H (HbH) Disease - LearnHaem | Haematology Made Simple HbH disease is characterised by a moderate anaemia (Hb typically ~80g L, but can range from 60-100g L) Haemolytic episodes are triggered by infections, especially parvovirus B19 infection and exposure to oxidant drugs Pregnancy exacerbates the anaemia due to a dilutional effect