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A review of kappa opioid receptor antagonists and their clinical trial . . . This review explores up to date advances on the relationship between the dynorphin KOR system with a particular focus on the KOR antagonist compounds tested as clinical candidates that could offer potential treatment options for CNS disorders
κ-opioid receptor - Wikipedia Recent epigenetic findings suggest that KOR antagonists, which block the hyperactive KOR system, might be a viable pharmacological approach for borderline personality disorder (BPD) treatment, particularly for anhedonia, suicidality, and dissociative symptoms
One of J Js blockbuster depression hopes has flamed out Johnson Johnson has decided to halt the development of selective kappa opioid receptor (KOR) antagonist aticaprant as a treatment for major depressive disorder (MDD), blowing a hole in its
Kappa Opioid Receptor Antagonists: A Comprehensive Review Kappa opioid receptor antagonists (KOR antagonists) represent a distinct class of compounds that have garnered significant interest in pharmacotherapy Unlike other opioid receptors, the kappa subtype plays a complex role in pain perception, mood regulation, and the modulation of addictive behaviors
Kappa Opioid Receptors (KORs) vs. Depression Stress-Related Brain . . . KOR Antagonists: Conversely, blocking KOR activity has been shown to produce antidepressant-like effects in animal models, reducing depressive-like behaviors and improving responses to stress This suggests a therapeutic potential for KOR antagonists in treating depression