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A suitable silicosis mouse model was constructed by repeated inhalation . . . In this study, we developed a silica-induced silicosis mouse model by repeated inhalation via the nose Moreover, an objective and comprehensive criterion for the generation of silica-induced silicosis in mice has been established by repeated silica exposure
Preclinical Mouse Model of Silicosis - PubMed This chapter describes a mouse model of silicosis which mimics clinical features of human silicosis, as well as methods for intranasal instillation of silica and disease analysis
A Silicosis Mouse Model Established by Repeated Inhalation of . . . This protocol describes a method for establishing a mouse model of silicosis through repeated exposure to silica suspensions via a nasal drip This model can efficiently, conveniently, and flexibly mimic the pathological process of human silicosis with high repeatability and economy
Chapter9 PreclinicalMouseModelofSilicosis - Springer In vivo mouse models of lung disease are valuable tools required to bridge the translational gap between in vitro cell culture and human disease This chapter describes a mouse model of silicosis which mimics clinical features of human silicosis, as well as methods for intranasal instillation of silica and disease analysis
Preclinical Mouse Model of Silicosis - Springer Nature Silicosis is an untreatable occupational lung disease caused by chronic inhalation of crystalline silica Cyclical release and reuptake of silica particles by macrophages and airway epithelial cells causes repeated tissue damage, characterized by … more
CONCISE REVIEW ON PATHOPHYSIOLOGY AND ANIMAL MODELS OF SILICOSIS Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation Experimental lung research 2006 Jan 1;32(5):181-99
Improving method for preparing mouse silicosis model - Patsnap The method is simple and easy in operation, simulates human silicosis process at a high degree and has the advantages of low mouse death rate, high model success rate and high operability
The Applicability of Mouse Models to the Study of Human Disease Using specific examples of mouse models of human lung disease, i e , asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis, this chapter explores the most salient features of mouse models of human disease and provides a full assessment of the advantages and limitations of these models, focusing on the relevance of disease
A Silicosis Mouse Model Established by Repeated Inhalation of . . . The pathophysiology, screening, and treatment of silicosis in humans have all been extensively studied using the mouse silicosis model By repeatedly making mice inhale CSD into their lungs, the mice can mimic the clinical symptoms of human silicosis