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Senescent immune cells release grancalcin to promote skeletal aging Here, we show that during aging in rats and mice proinflammatory and senescent subtypes of immune cells, including macrophages and neutrophils, accumulate in the bone marrow and secrete abundant grancalcin The injection of recombinant grancalcin into young mice was sufficient to induce premature skeletal aging
ORCID Review activity for Nature aging (1) Review activity for Signal transduction and targeted therapy (1)
Senescent immune cells release grancalcin to promote skeletal aging In this study, we report that proinflammatory and senescent subtypes of immune cells, including macrophages and neutrophils, accumulate in the bone marrow during aging in rats and mice and secrete abundant quantities of grancalcin (GCA) to induce an imbalance in osteogenesis versus adipogenesis of bone marrow stromal cells (BMSCs)
Senescent immune cells release grancalcin to promote skeletal aging Aging is marked by reduced osteogenesis and increased adipogenesis of bone marrow stromal cells, leading to bone fragility Here, Li et al show that senescent immune cells contribute to this process by accumulating in the bone marrow, where they secrete the protein grancalcin, which suppresses bone turnover and promotes marrow fat accumulation
Changjun Li - Xiangya Hospital, Central South University . . . Age-related Secretion of Grancalcin by Macrophages Induces Skeletal Stem progenitor Cell Senescence During Fracture Healing Zeqin Wen, Yilun Wang, Xiaoxiao Li, Yuqing Zhang, Junqing Xie, Houchen Lyu, Changjun Li, Jie Wei, Guanghua Lei, Chao Zeng
Changjun Li - Google Scholar Gehua Zhen Assistant Professor, Orthopaedic Surgery, Johns Hopkins University School of Medicine Verified email at jhmi edu