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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis Methods In a phase 3, randomized, controlled trial, we assigned adults with biopsy-proven active lupus nephritis in a 1:1 ratio to receive obinutuzumab in one of two dose schedules (1000 mg on day
Structured Exercise after Adjuvant Chemotherapy for Colon Cancer Methods In this phase 3, randomized trial conducted at 55 centers, we assigned patients with resected colon cancer who had completed adjuvant chemotherapy to participate in a structured exercise
new england journal 5 cm; or T3, >5 cm) — that was treated with mastectomy, an axillary procedure, and systemic therapy Patients were assigned to undergo chest-wall irradiation (40 to 50 Gy; the irradiation group