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Real‐time assessment of 13C metabolism reveals an early lactate . . . Intracranial hypertension is a severe complication of acute liver failure (ALF) secondary to brain edema The pathogenesis of cerebral edema in ALF is not clear, but seems to be related to energy metabolism in which lactate may have an important role The aim of this study was to follow the synthesis of brain lactate using a novel in vivo metabolic technology in a rat model of ALF Time
Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance . . . Following acute liver failure, 13 C MRS I of hyperpolarized [1- 13 C]pyruvate revealed increased brain hyperpolarized 13 C lactate:pyruvate and hyperpolarized 13C alanine:pyruvate before the appearance of clinical symptoms, and further increases of these ratios with disease progression [28]
Hyperpolarized [1-¹³C] pyruvate MRSI reveals a diet . . . - ScienceDirect We evaluated altered cardiac metabolism in Zucker Spontaneously Hypertensive Fatty (ZSF1) rats fed an isocaloric high-fat diet versus normal chow using hyperpolarized (HP) [1-13C]pyruvate MR spectroscopic imaging (MRSI) This technique exploits remarkable signal enhancement to track the metabolic fate of injected HP [1- 13 C]pyruvate in vivo, allowing a simultaneous assessment of multiple