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Tesofensine - an overview | ScienceDirect Topics Tesofensine Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease Development of the compound for these neurological indications was unsuccessful but significant weight loss was reported during the clinical trials in Parkinson's disease 166 Hence, tesofensine is
Tesofensine - an overview | ScienceDirect Topics Tesofensine (with metoprolol) Tesofensine is a presynaptic uptake inhibitor of noradrenaline, dopamine and serotonin A phase II, randomised, double-blind, placebo-controlled trial included 203 obese patients (body-mass index 30–≤40 kg m2) who were prescribed an energy restricted diet together with either tesofensine 0 25 to 1 0 mg or placebo, once daily for 24 weeks [30] The two highest
Tesofensine - an overview | ScienceDirect Topics Tesofensine Tesofensine is an inhibitor of neuronal reuptake of dopamine, noradrenaline, and serotonin There has been considerable interest in this investigational drug for weight reduction as an adjunct to energy restriction Placebo-controlled studies In a phase II clinical trial of tesofensine in Denmark there was a significant reduction in body weight compared with placebo [118C] The
Tesofensine - an overview | ScienceDirect Topics Tesofensine is a compound originally developed for the treatment of neurological diseases such as Alzheimer's and Parkinson's However, it was found to cause significant weight loss during clinical trials in Parkinson's disease, leading to its current development for the treatment of obesity and type 2 diabetes AI generated definition based on: Animal and Translational Models for CNS Drug
Tesofensine - Weight Loss - AnabolicMinds. com Tesofensine has in previous studies provided a clinical significant and convincing weight loss in obese patients Therefore, this study may lead to market approval of a novel and highly effective treatment in Mexico, where overweight and obesity represents a severe health problem," says Jørgen Drejer, CEO of Saniona