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Alectinib in Resected ALK-Positive Non–Small-Cell Lung Cancer Platinum-based chemotherapy is the recommended adjuvant treatment for patients with resectable, ALK-positive non–small-cell lung cancer (NSCLC) Data on the efficacy and safety of adjuvant
ALK+ NSCLC Treatment Guidelines Use of ALK TKIs is effective for treatment of patients with ALK+ NSCLC and CNS involvement, and evidence supports alectinib, brigatinib or ceritinib in this setting as first-line therapy
Anaplastic lymphoma kinase (ALK)-positive advanced non-small . . . The molecular pathogenesis, clinical features, and treatment of NSCLC associated with the ALK fusion oncogene are discussed here An overview of the treatment of metastatic NSCLC, ALK-positive early NSCLC, and the methods and indications for molecular testing are presented elsewhere
Real-world treatment sequencing and effectiveness of second . . . With multiple targeted therapies approved for anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC), it is increasingly important to understand outcomes with various sequences of next-generation ALK tyrosine kinase inhibitors (TKIs) We describe contemporary sequencing patterns and treatment effectiveness of first-line (1L) and second-line (2L) treatments in
NCCN Updates Guidelines for Non–Small Cell Lung Cancer Molecular testing is considered essential for patients with nonmetastatic NSCLC, particularly for identifying EGFR and ALK mutations that influence neoadjuvant, adjuvant, and consolidation treatment strategies At a minimum, testing for EGFR, ALK, and PD-L1 should be performed for all resectable Stage IB–IIIB tumors
New Targeted Therapy Strategies for Addressing Non-Small Cell . . . ALK-Fusion Positive Lung Cancer ALK fusions occur in up to 5% of patients diagnosed with NSCLC (10) Six tyrosine kinase inhibitors (TKIs) spanning three generations have been approved for ALK fusion-positive NSCLC As initial therapy, all of these agents produce ORRs from 70% to 80%, and each successive generation has improved CNS activity and median PFS However, effective treatment
Emerging Strategies for ALK+ NSCLC - OncLive EP 1 ALK Alterations and Treatment Options for ALK+ NSCLC EP 2 Long-Term Data in ALK+ NSCLC EP 3 Spotlight on ROS1-Targeted Therapies in Advanced NSCLC EP 4 Treatment Options for ROS1
Evaluating Diagnostic and Treatment Timelines for ALK . . . MicroabstractThe ALK Life Study analyzed diagnostic and treatment timelines in 1288 ALK-positive NSCLC patients from 71 countries The median time to diagnosis was 45 days, and time to TKI treatment was 30 days for advanced-stage patients Younger age, comorbidities, and geographic factors were linked to delays Outcomes may be improved by raising awareness amongst clinicians of the frequency
ALK-Positive NSCLC Treatment: Key Strategies Explained Intro Non-small cell lung cancer (NSCLC) plays a significant role in cancer morbidity and mortality globally Within this realm, ALK-positive subtypes are distinguished by specific genetic rearrangements involving the anaplastic lymphoma kinase gene These rearrangements lead to unique characteristics in tumor behavior and response to treatment, making it essential for health professionals and