copy and paste this google map to your website or blog!
Press copy button and paste into your blog or website.
(Please switch to 'HTML' mode when posting into your blog. Examples: WordPress Example, Blogger Example)
Input Form:Deal with this potential dealer,buyer,seller,supplier,manufacturer,exporter,importer
(Any information to deal,buy, sell, quote for products or service)
Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS . . . Moreover, we discussed the versatile roles of tumor microenvironment components during RT, how the innate immune sensing of RT-induced genotoxicity, through the cGAS-STING pathway, might link the anti-tumor immune response, radiation-induced necrosis and radiation-induced fibrosis, and how a better understanding of the switch between favorable
Frontiers Moreover, we discussed the versatile roles of tumor microenvironment components during RT, how the innate immune sensing of RT-induced genotoxicity, through the cGAS-STING pathway, might link the anti-tumor immune response, radiation-induced necrosis and radiation-induced fibrosis, and how a better understanding of the switch between favorable
Crossed Pathways for Radiation-Induced and Immunotherapy . . . - Frontiers Activation of the cGAS-STING pathway can not only mediate innate antitumor immunity and produce synergistic antitumor effects with immune checkpoint inhibitors but also can elicit a robust inflammatory response by activating NF-κB and stimulating the production of inflammatory cytokines such as TNF, IL-1β, and IL-6 (181, 183)
Harnessing the cGAS-STING pathway to potentiate radiation therapy . . . In this review, we cover the current understanding of how radiation therapy, which uses ionizing radiation to kill cancer cells, mediates an anti-tumor immune response through the cGAS-STING pathway, and how STING agonists might potentiate this
Radiation-Induced Chromosomal Aberrations and Immunotherapy . . . Recent evidence has shown that the presence of cytosolic DNA activates immune response via the cyclic GMP–AMP synthase stimulator of interferon genes pathway, which induces type I interferon transcription Cytosolic DNA can be found after exposure to ionizing radiation either as MN or as small fragments leaking through nuclear envelope ruptures
Frontiers | The future of cancer treatment: combining radiotherapy with . . . The primary goal of RT is to enhance the delivery of radiation to the tumor, thereby ensuring local control while minimising radiation exposure to the adjacent healthy tissue Advancements like High Linear Energy Transfer (LET) or Intensity-Modulated RT (IMRT) have significantly improved the therapeutic ratio (Elshaikh et al , 2006)
Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy In this review, we will discuss how the innate immune system shapes anti-tumor immunity following radiation and highlight key strategies directed at the innate immune response to enhance the efficacy of radiation
Immune modulatory roles of radioimmunotherapy: biological principles . . . Radiation therapy (RT) not only can directly kill tumor cells by causing DNA double-strand break, but also exerts anti-tumor effects through modulating local and systemic immune responses The immunomodulatory effects of RT are generally considered as a double-edged sword
Cellular RNA and DNA sensing pathways are essential for the dose . . . Circulating monocytes are important players of the inflammatory response to ionizing radiation (IR) These IR-resistant immune cells migrate to radiation-damaged tissues and differentiate into macrophages that phagocytize dying cells, but also facilitate inflammation
Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS . . . Organs at risks and the tumor microenvironment (e g endothelial cells, macrophages and fibroblasts) often limit the radiation regimen effects due to adverse toxicities Here, we reviewed how RT can modulate the immune response involved in the tumor control and side effects associated with inammatory processes