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Gasdermin D permeabilization of mitochondrial inner and outer membranes . . . Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT) rapidly damaged both inner and outer mitochondrial membranes (OMMs) leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation (OXPHOS), and release of mitochondrial proteins and DNA from the matrix and
Issue: Immunity - Cell Press Miao, Jiang, Chang et al provide insight into the events connecting GSDMD cleavage and pyroptosis, revealing a critical role for mitochondrial damage in this form of cell death Mechanistically, the N-terminal GSDMD fragment (GSDMD-NT; brown sticks) rapidly forms pores in the mitochondrial inner and outer membranes in a manner dependent on the
Immunity封面文章揭示焦亡细胞线粒体损伤新机制 - 腾讯网 该研究揭示了一种新型由Gasdermin成孔蛋白介导的线粒体细胞死亡通路，为病原体感染及肿瘤等相关疾病的预防 治疗提供了新的思路与靶点。 封面图来源：123RF 参考资料： [1] 研究揭示焦亡细胞线粒体损伤新机制 Retrieved- November 16, 2023 from http: www cas ac cn syky 202311 t20231116_4985901 shtml 原始论文： [1] Miao et al , Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis Immunity (2023)
GSDMD-mediated mitochondrial dysfunction in marginal cells: A . . . - PNAS Herein, we demonstrated that pyroptosis—a recently identified inflammatory type of regulated cell death dependent on gasdermin D (GSDMD)—was activated in the cochleae of cisplatin-treated mice, causing CIHL Meanwhile, treatment with the GSDMD inhibitor necrosulfonamide alleviated CIHL in these mice
Gasdermin D permeabilization of mitochondrial inner and outer membranes . . . Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT) rapidly damaged both inner and outer mitochondrial membranes (OMMs) leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation (OXPHOS), and release of mitochondrial proteins and DNA from the matrix and in
Gasdermin D triggers cardiolipin-driven mitochondrial damage and . . . In a remarkable recent study, Miao et al reveal that gasdermin D N-terminal (GSDMD-NT) instigates mitochondrial damage in pyroptosis by forming pores in inner and outer mitochondrial membranes (OMMs) The authors highlight the key role of mitochondrial cardiolipin in the action of GSDMD-NT, and sig …
Gasdermin D permeabilization of mitochondrial inner and outer membranes . . . Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT) rapidly damaged both inner and outer mitochondrial membranes (OMMs) leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation (OXPHOS), and release of mitochondrial proteins and DNA from the matrix and in
Gasdermin D permeabilization of mitochondrial inner and outer membranes . . . Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT) rapidly damaged both inner and outer mitochondrial membranes leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation and release of mitochondrial proteins and DNA from the matrix and intermembrane space