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Application of a label-free and domain-specific free thiol method in . . . Characterization of free thiol variants in antibody therapeutics is important for biopharmaceutical development, as the presence of free thiols may have an impact on aggregate formation, structural and thermal stability, as well as antigen-binding potency of monoclonal antibodies
Charge Variant Analysis of USP Monoclonal Antibody Reference Standards Several PTMs which occur during biosynthesis confer variation in charge, either by direct charge diference or by inducing conformational changes These changes can impact quality, stability, and potency of a mAb
A Protocol for the Determination of Free Thiols - UMKC Free thiol can be determined in solutions collected from chromatographic separations or from reconstituted lyophilized samples This protocol has been used for peptides (3 to 26mer) with a single Cys residue present and lacking tryptophan
Revolutionary Method Detects Free Thiols in mAbs! Monoclonal antibody processing requires accurate measurement of free thiols to mitigate risks of aggregation and denaturation Current analytical methods suffer from low sensitivity, applicability, and complicated sample preparations
Chromatographic analysis of the acidic and basic species of recombinant . . . The existence of multiple variants with differences in either charge, molecular weight or other properties is a common feature of monoclonal antibodies These charge variants are generally referred to as acidic or basic compared with the main species