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Multiphysics pharmacokinetic model for targeted nanoparticles The purpose of this study was to develop a physics-based multiscale PBPK compartmental model for determining continuous NP biodistribution We successfully developed two versions of a physics-based compartmental model, models A and B, and validated the models with experimental data
Multiphysics modeling and simulation of local transport and absorption . . . Herein, we developed a bottom-up multiphysics computational model to simulate the injection and absorption processes of LNPs in muscular tissues Our purpose was to seek underlying connections between formulation attributes and local exposure kinetics of LNPs and the delivered drug
Physiologically Based Pharmacokinetic Modeling of Nanoparticles Nanoparticles can be engineered to have different properties such as size, shape, charge, and surface chemistry,2 thus providing a versatile platform for modifying the delivery and pharmacological performance of the loaded drugs From a formulation perspective, various nanoparticles have been used to modify the release pro le fi
Multiphysics pharmacokinetic model for targeted nanoparticles The goal of the compartmental model is to develop a basic framework for determining targeted NP biodistribution in a murine model that can act as a predictive model when provided with experimentally and empirically derived parameters
Multiphysics pharmacokinetic model for targeted nanoparticles A branched model was developed to enable the model to account for varying NP sizes With the help of the branched model, we were able to show that branching in vasculature causes enhanced uptake
Physiologically Based Multiphysics Pharmacokinetic Model for . . . The purpose of this study was to develop a physics-based multiscale PBPK compartmental model for determining continuous NP biodistribution We successfully developed two versions of a physics-based compartmental model, models A and B, and validated the models with experimental data
Review of: Physiologically Based Multiphysics Pharmacokinetic Model . . . This paper addresses a novel topic, and it is important that we better understand the fate of nanoparticles in the body The authors cover a lot of territory in this paper, including methods for solving stiff differential equations
Multiphysics pharmacokinetic model for targeted nanoparticles A membrane-limited physiologically based pharmacokinetic (PBPK) model for polyethylene glycol-coated gold (Au) NPs (PEG- coated AuNPs) was developed in mice, providing useful insights into the size, time, and species dependence of NP pharmacokinetics