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Ym155 Induces Oxidative Stress-Mediated DNA Damage and Cell . . . In the present study, we focused on testing the effects of YM155 in ATC cells including anti-proliferative activity, induction of DNA damage, cell cycle arrest, and apoptosis We also tested the effect of YM155 on primary benign thyroid cells (PBTCs)
Ym155 Induces Oxidative Stress-Mediated DNA Damage and . . . - MDPI In the present study, we focused on testing the effects of YM155 in ATC cells including anti-proliferative activity, induction of DNA damage, cell cycle arrest, and apoptosis We also tested the effect of YM155 on primary benign thyroid cells (PBTCs)
Ym155 Induces Oxidative Stress-Mediated DNA Damage and Cell . . . Our data show that YM155 inhibited proliferation of ATC cell lines while sparing normal thyroid cells, suggesting a high therapeutic window YM155-induced DNA damage was detected by measuring phosphorylation of γ-H2AX as a marker for DNA double-strand breaks
Validating the Role of ROS in YM155-Induced Apoptosis: A . . . Executive Summary YM155, a small molecule initially identified as a survivin suppressant, has been shown to induce apoptosis in a variety of cancer cell lines Emerging evidence strongly suggests that its primary mode of action involves the generation of mitochondrial ROS, which subsequently triggers DNA damage and downregulation of the anti-apoptotic protein survivin, leading to programmed
YM155 Technical Support Center: Managing Off-Target Effects . . . References 1 Ym155 Induces Oxidative Stress-Mediated DNA Damage and Cell Cycle Arrest, and Causes Programmed Cell Death in Anaplastic Thyroid Cancer Cells - PMC [pmc ncbi nlm nih gov] 2 Generation of reactive oxygen species is the primary mode of action and cause of survivin suppression by sepantronium bromide (YM155) - PMC [pmc ncbi nlm nih
Sepantronium Bromide | 781661-94-7 | Benchchem 7 Ym155 Induces Oxidative Stress-Mediated DNA Damage and Cell Cycle Arrest, and Causes Programmed Cell Death in Anaplastic Thyroid Cancer Cells - PMC [pmc ncbi nlm nih gov] 8 Generation of reactive oxygen species is the primary mode of action and cause of survivin suppression by this compound (YM155) - PMC [pmc ncbi nlm nih gov] 9