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Muscle-Invasive Bladder Cancer - Urology Care Foundation Muscle-invasive bladder cancer (MIBC) is a cancer that is found in the detrusor muscle of the bladder The detrusor muscle is the thick muscle deep in the bladder wall This cancer is more likely to spread to other parts of the body
Muscle Invasive Bladder Cancer: Causes, Diagnosis Treatment What is Muscle Invasive Bladder Cancer (MIBC)? Muscle invasive bladder cancer (MIBC) is a cancer that spreads into the detrusor muscle of the bladder The detrusor muscle is the thick muscle deep in the bladder wall This cancer is more likely to spread to other parts of the body
FDA Approves Enfortumab Vedotin Plus Pembrolizumab for MIBC The FDA approved enfortumab vedotin and pembrolizumab for MIBC, following a priority review of their sBLA for neoadjuvant and adjuvant use The phase 3 EV-303 trial showed a 60% reduction in recurrence, progression, or death risk and a 50% reduction in death risk compared to surgery alone Improved
FDA approves pembrolizumab plus enfortumab vedotin for cisplatin . . . On November 21, 2025, the FDA approved pembrolizumab (Keytruda) and pembrolizumab and berahyaluronidase alfa-pmph (Keytruda QLEX), each in combination with enfortumab vedotin-ejfv (Padcev), as perioperative regimens for patients with muscle-invasive bladder cancer (MIBC) who are ineligible for cisplatin-based chemotherapy 1
EAU Guidelines on MIBC - Introduction - Uroweb This overview represents the updated European Association of Urology (EAU) Guidelines for Muscle-invasive and Metastatic Bladder Cancer (MIBC) The aim is to provide practical recommendations on the clinical management of MIBC